API & Intermediates

Benfotiamine

Benfotiamine is a synthetic, fat-soluble derivative of thiamine (Vitamin B1) known for its significantly higher bioavailability compared to water-soluble thiamine salts. By effectively increasing intracellular thiamine diphosphate levels, it plays a critical role in activating the enzyme transketolase, which redirects glucose metabolites away from harmful metabolic pathways. It is widely utilized in therapeutic formulations targeting diabetic complications and neurological health.

Technical Specifications

Chemical NameS-benzoylthiamine O-monophosphate
CAS Number22457-89-2
Molecular FormulaC19H23N4O6PS
Molecular Weight466.45 g/mol
AppearanceWhite to off-white crystalline powder
SolubilitySparingly soluble in water; freely soluble in ethanol
StorageStore in a cool, dry place, protected from light (2°C to 25°C)

Recommended Applications

  • Neurological Care: A primary agent in the management of diabetic sensorimotor polyneuropathy, supporting nerve health and reducing neuropathic pain.
  • Metabolic Support: Used in formulations to combat oxidative stress and the formation of Advanced Glycation End-products (AGEs) in diabetic patients.
  • Cognitive & Vascular Health: Increasingly utilized in therapeutic research for cognitive vitality, endothelial function, and vascular health support.