Excipient

Croscarmellose Sodium

Croscarmellose Sodium is a cross-linked sodium carboxymethyl cellulose used as a super-disintegrant in solid dosage forms. Its rapid swelling on contact with water ensures fast tablet disintegration and drug dissolution.

Technical Specifications

Chemical NameCross-linked sodium carboxymethyl cellulose
CAS Number74811-65-7
AppearanceWhite to grayish-white, fibrous, hygroscopic powder
Substitution Degree0.60 – 0.85
Loss on Drying< 10.0%
pH (1% aqueous solution)5.0 – 7.0
SolubilityInsoluble in water (but swells); practically insoluble in ethanol
StorageStore in a tightly closed, moisture-proof container

Recommended Applications

  • Super-Disintegrant: Ideal for immediate-release tablets, providing faster disintegration times.
  • Direct Compression: Maintains excellent tableting properties without affecting hardness.
  • Wet Granulation: Effective in both wet granulation and direct compression processes.
  • Nutraceuticals: Widely used in herbal supplements and multivitamin tablets to improve bioavailability.